Exosomes, tiny extracellular vesicles secreted by cells, play a vital role in skin rejuvenation and aesthetics by facilitating cell-to-cell communication and delivering bioactive molecules like growth factors, proteins, and RNA. In aesthetic medicine, exosomes derived from stem cells are particularly valued for their ability to stimulate collagen production, reduce inflammation, and promote skin regeneration. When applied topically or through microneedling, they enhance skin texture, tone, and elasticity, leading to a more youthful appearance. Their regenerative properties make them a promising, non-invasive option for addressing signs of aging, scars, and overall skin vitality.